Warfarin's fewer potent R-enantiomer is metabolized partly by CYP3A4 (and also CYP1A2 and CYP2C19). Check INR extra commonly if coadministered with inhibitors of these isoenzymes and alter warfarin dose if wanted.
It should be used with caution in patients with uncontrolled hypertension, unstable angina, or the latest myocardial infarction.
Monitor Intently (1)modafinil improves amounts of eluxadoline by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Check. To be a precautionary evaluate on account of incomplete info on the metabolism of eluxadoline, use caution when coadministered with solid CYP2C19 inhibitors.
istradefylline will increase the stage or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
apalutamide will decrease the level or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications which have been CYP3A4 substrates may result in reduced publicity to those prescription drugs.
Working with this medication with any of the following medicines is not really advised. Your physician may make a decision not to treat you using this type of medication or modify some of the other medicines you're taking.
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crizotinib improves levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Dose reduction could possibly be needed for coadministered medications that are predominantly metabolized by CYP3A.
larotrectinib will increase the degree or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
modafinil will increase the stage or outcome of diazepam intranasal by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Solid or moderate CYP2C19 inhibitors may lessen fee of diazepam elimination, therefore expanding adverse reactions to diazepam.
Stiripentol is a CYP3A4 inhibitor and inducer. Keep track of CYP3A4 substrates coadministered with stiripentol for elevated or reduced effects. CYP3A4 substrates might need dosage adjustment.
No distinct antidote exists with the poisonous consequences of a PROVIGIL overdose. These kinds of overdoses should be managed with largely supportive treatment, which includes cardiovascular checking.
efavirenz will decrease the extent or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
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